Promethazine

Laboratory Report # 3.2 Title:         Promethazine 0.2% Syrup          date stamp:                   learner Name: 1.         Describe the dispensing directions for the preparation:         A. Indication and evaluate motion:                           Promethazine HCL is a powerful antihistamine drug employ to track allergic conditions and,                  because of the sedative action, insomnia. It is also apply as an anti-tussive in cough mixings.         Promethazine can be administered by emit or injection.         B. Directions/administration/use: Sig:         TAKE sensation teaspoonful OF SYRUP BY MOUTH AT MEALTIMES AND AT BEDTIME.         C. Precautions/DI: elapse medication out of r distributively of children Do non confuse alcohol while on this medication Contraindications: ·         children low 2yrs ·         SC or intra-arterial injection ·         narrow-angle glaucoma ·         prostatic hypertrophy ·         bladder or pyeloduodenal obstruction ·         MAOI therapy ·         hypersensitivity to promethazine and other phenothiazines indecorous Reactions: drowsiness dizziness ·         xerostomia ·          tautologicpyramidal reactions                  Drug Interactions: belladonna benztropine cabergoline cisapride dofetilide gatifloxacin grepafloxacin halofantrine levofloxacin lithium meperidine hydrochloride moxifloxacin orphenadrine pimozide porfimer procyclidine sotalol sparfloxacin tramadol trihexyphenidyl          D. Storage: Keep the sirup at means temperature, away from heat, light, and moisture. Do not freeze.         E. preoccupied paneling: ! Use your medicine as soon as you commend that you have missed your venereal infection. If it is nearly time for your b magnitudeing dose, hold back until whence to use the medicine and rake the missed dose. You should not use two doses at adept time. 2.         Purpose of each excipient used in the experiment: deep brown         -         flavoring mover Sucrose         -         sweetening mover, suspending and viscosity-increasing agent. liquifiable Glucose         -         to contribute calories, taste, and to improve cristal of atomic number 11                                    and piddle across the intestinal barrier through osmosis          Glycerin         -         used as a demulcent in cough preparations for soothing and protecting                Â Â Â          the mucous membranes and relieves irritation. When administered by                            backtalk or parenterally, glycerol increases the plasma osmolality,                           resulting in the movement of water by osmosis from the extra vascular                           spaces into the plasma. sodium Chloride-         electrolyte - source of sodium (Na+), used in combination with glucose for oral rehydration in shrewd diarrhea. Vanillin         -         flavoring/perfuming agent Sodium Benzoate         preservative with antibacterial and anti-fungal properties complete(a) Water         -         diluent 3.          coming into court your calculations and compounding (in steps):         Calculations: Promethazine HCL         2 g   Â!  Â Â Â Â Â          x         (90mL / super acidmL)         =         0.18 g Cocoa         180 g         x         (90mL / 1000mL)         =         16.

2 g Sucrose         600 g         x         (90mL / 1000mL)         =         54 g Liquid Glucose         180 g         x         (90mL / 1000mL)         =         16.2 g Glycerin         50 mL         x         (90mL / 1000mL)         =    Â Â Â Â Â Â 4.5 mL x (1.25g/mL) = 5.625 g Sodium Chloride         2.0 g         x         (90mL / 1000mL)         =         0.18g sp. gravity Vanillin         0.2 g         x         (90mL / 1000mL)         =         0.018 g Sodium Benzoate         1.0 g         x         (90mL / 1000mL)         =         0.09 g P. Water         1000 mL         x         (90mL / 1000mL)         =         90 mL Ft. 90 mL         Promethazine:         (2 g / 1000 mL)         x 100 % = 0.2% sirup         1 Tsp = 5 mL x (0.2 % / 100 %) = 0.01 g x (1000 mg / 1 g) = 10 mg / dose Preparation: The sucrose and cocoa were merge together in a beaker. To t his smorgasbord, the glucose, glycerin and vanillin w! ere gradually added. The sodium benzoate and sodium chloride were and then dissolved in a undersize amount (30 mL) of furious water. The promethazine HCL was then added to the solution and was complex well. The contents were then transferred to the mixture in the beaker. The entire mixture was brought to a grind and the boiling temperature was maintained for 2 minutes. The mixture was allowed to cool to room temperature and the volume was brought up to 90 mL by adding additive pure water. If you want to get a full essay, order it on our website: OrderEssay.net

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